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Jak/Stat Pathway

Chemical Structure Cat. No. Product Name CAS No.
Filgotinib maleate Chemical Structure
 BCP49095 Filgotinib maleate 1802998-75-9
Filgotinib maleate is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn's disease.
Solcitinib Chemical Structure
 BCP23893 Solcitinib 1206163-45-2
Solcitinib is a Janus kinase 1 (JAK1) inhibitor. Solcitinib may be potential useful for treatment of psoriasis，systemic lupus erythematosus, ulcerative colitis.
Tyrphostin AG 835 Chemical Structure
 BCP24136 Tyrphostin AG 835 133550-37-5
Tyrphostin AG 835 is an EGRF inhibitor with antitumor activities.
PD 161570 Chemical Structure
 BCP24138 PD 161570 192705-80-9
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor.
Tyrphostin RG 13022 Chemical Structure
 BCP24139 Tyrphostin RG 13022 136831-48-6
RG 13022 is a tyrosine kinase inhibitor that selectively inhibits epidermal growth factor receptor, epidermal factor-stimulated HER14 cell proliferation, and tumor growth in vivo.
BP-1-102 Chemical Structure
 BCP24676 BP-1-102 1334493-07-0
BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 μM.
Pacritinib citrate Chemical Structure
 BCP48998 Pacritinib citrate 1228923-42-9
Pacritinib Citrate is the citrate salt form of pacritinib, an orally bioavailable inhibitor of Janus kinase 2 (JAK2), the JAK2 mutant JAK2V617F and FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity.
Ruxolitinib racemic Chemical Structure
 BCP25428 Ruxolitinib racemic 1160597-27-2
Ruxolitinib racemic is a Janus-associated kinase (JAK) inhibitor.
Tyrphostin AG 555 Chemical Structure
 BCP25507 Tyrphostin AG 555 133550-34-2
AG555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor.
BLU-945 Chemical Structure
 BCP45854 BLU-945 2660250-10-0
BLU-945 is designed to target and selectively inhibit the EGFR T790M/C797S and T790M resistant mutations.
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