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Jak/Stat Pathway

Chemical Structure Cat. No. Product Name CAS No.
Amphiregulin, Human Recombinant Chemical Structure
BCP44759 Amphiregulin, Human Recombinant 117147-70-3
Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-a receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts.
Almonertinib hydrochloride Chemical Structure
BCP44623 Almonertinib hydrochloride 2134096-03-8
Almonertinib hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
Stafia-1 Chemical Structure
BCP44460 Stafia-1 Stafia-1
Stafia-1 decreases pSTAT5a expression significantly, and has no obvious inhibition on pSTAT5b.
PF-06459988 Chemical Structure
BCP44108 PF-06459988 1428774-45-1
PF-06459988 is an orally available, small molecule, third-generation, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms with potential antineoplastic activity.
Ilginatinib Chemical Structure
BCP44119 Ilginatinib 1239358-86-1
Ilginatinib is an orally bioavailable, small molecule inhibitor of Janus-associated kinase 2 (JAK2) and Src-family kinases, with potential antineoplastic activity. JAK2/Src inhibitor NS-018 competes with ATP for binding to JAK2 as well as the mutated form JAK2V617F, thereby inhibiting the activation of JAK2 and downstream molecules in the JAK2/STAT3 (signal transducer and activator of transcription 3) signaling pathway that plays an important role in normal development, particularly hematopoiesis. In addition, NS-018 inhibits the Src family tyrosine kinases. This eventually leads to the induction of tumor cell apoptosis.
STAT3-IN-3 Chemical Structure
BCP43810 STAT3-IN-3 2361304-26-7
STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3).
PIM1-IN-1 Chemical Structure
BCP43782 PIM1-IN-1 1417630-95-5
PIM1-IN-1 is a potent and highly selective inhibitor of PIM1/3(IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively),with Antiproliferative and anti-cancer activity.
AZ7550 hydrochloride Chemical Structure
BCP43207 AZ7550 hydrochloride 2309762-40-9
AZ-7550 is a metabolite of Osimertinib.
Aurora B inhibitor 1 Chemical Structure
BCP42843 Aurora B inhibitor 1 937276-52-3
Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor extracted from patent WO2007059299A1, compound 1-3, has a Ki value of <0.010 uM.
STAT3-IN-1 Chemical Structure
BCP42674 STAT3-IN-1 2059952-75-7
STAT3-IN-1 is a novel selective and orally active STAT3 inhibitor.
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