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Jak/Stat Pathway

Chemical Structure Cat. No. Product Name CAS No.
QL-1200186 Chemical Structure
BCP49631 QL-1200186 2848664-42-4
QL-1200186 is an orally active and selective TYK2 inhibitor.
Befotertinib Chemical Structure
BCP49575 Befotertinib 1835667-63-4
Befotertinib is the third-generation EGFR tyrosine kinase inhibitor. Befotertinib can be used for the research of EGFR T790M-positive non-small cell lung cancer (NSCLC).
SBT-101 Chemical Structure
BCP49363 SBT-101 SBT-101
SBT101 is the first investigational adeno-associated virus (AAV) gene therapy for AMN.
EMI1 Chemical Structure
BCP49115 EMI1 35773-42-3
EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC).
Filgotinib maleate Chemical Structure
BCP49095 Filgotinib maleate 1802998-75-9
Filgotinib maleate is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn's disease.
Solcitinib Chemical Structure
BCP23893 Solcitinib 1206163-45-2
Solcitinib is a Janus kinase 1 (JAK1) inhibitor. Solcitinib may be potential useful for treatment of psoriasis,systemic lupus erythematosus, ulcerative colitis.
Tyrphostin AG 835 Chemical Structure
BCP24136 Tyrphostin AG 835 133550-37-5
Tyrphostin AG 835 is an EGRF inhibitor with antitumor activities.
PD 161570 Chemical Structure
BCP24138 PD 161570 192705-80-9
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor.
Tyrphostin RG 13022 Chemical Structure
BCP24139 Tyrphostin RG 13022 136831-48-6
RG 13022 is a tyrosine kinase inhibitor that selectively inhibits epidermal growth factor receptor, epidermal factor-stimulated HER14 cell proliferation, and tumor growth in vivo.
BP-1-102 Chemical Structure
BCP24676 BP-1-102 1334493-07-0
BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 μM.
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