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Jak/Stat Pathway

Chemical Structure Cat. No. Product Name CAS No.
SC-1 Chemical Structure
BCP46435 SC-1 1313019-65-6
SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.
AZD4205 Chemical Structure
BCP46221 AZD4205 2091134-35-7
AZD4205 is a highly potent JAK1-selective kinase inhibitor with excellent preclinical pharmacokinetics with potential for further clinical development. JAK1 is part of the JAK1/signal transducer and activator of transcription (STAT) axis, which plays an important role in tumour escape from EGFR-targeted treatment.
Ifidancitinib Chemical Structure
BCP46085 Ifidancitinib 1236667-40-5
Ifidancitinib is a Janus kinase inhibitor.
Ritlecitinib tosylate Chemical Structure
BCP45991 Ritlecitinib tosylate 2192215-81-7
Ritlecitinib, also known as PF-06651600, is a potent and selective JAK3 inhibitor.
Deuruxolitinib phosphate Chemical Structure
BCP45990 Deuruxolitinib phosphate 2147706-60-1
Deuruxolitinib(CTP-543), an oral inhibitor of Janus kinases JAK1 and JAK2, as a potential treatment for alopecia areata.
JAK-IN-5 Chemical Structure
BCP45656 JAK-IN-5 2096999-92-5
JAK-IN-5 is an inhibitor of JAK.
Tyk2-IN-5 Chemical Structure
BCP45577 Tyk2-IN-5 1797432-62-2
Tyk2-IN-5 is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα.
Upadacitinib hemihydrate Chemical Structure
BCP41039 Upadacitinib hemihydrate 2050057-56-0
Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis.
Amphiregulin, Human Recombinant Chemical Structure
BCP44759 Amphiregulin, Human Recombinant 117147-70-3
Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-a receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts.
Almonertinib hydrochloride Chemical Structure
BCP44623 Almonertinib hydrochloride 2134096-03-8
Almonertinib hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
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