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MAPK Pathway

Chemical Structure Cat. No. Product Name CAS No.
ASN007 benzenesulfonate Chemical Structure
 BCP48484 ASN007 benzenesulfonate 2055597-39-0
ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK. ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancers driven by RAS mutations.
p38-α MAPK inhibitor 1 Chemical Structure
 BCP48493 p38-α MAPK inhibitor 1 443913-15-3
p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.
ASN007 Chemical Structure
 BCP48479 ASN007 2055597-12-9
ASN007 is a potent and oral of ERK. ASN007 inhibits ERK1/2 with low single-digit nM IC50 values. ASN007 has the potential to be used to study cancers driven by RAS mutations.
KG5 Chemical Structure
 BCP46930 KG5 877874-85-6
KG 5 is an orally available PDGFRß and B-Raf allosteric inhibitor.
MAP4K4-IN-3 Chemical Structure
 BCP46896 MAP4K4-IN-3 1811510-58-3
MAP4K4-IN-3 may be a viable target for antidiabetic agents, a serine/threonine protein kinase.
ONC-201 Dihydrochloride Chemical Structure
 BCP46830 ONC-201 Dihydrochloride 1638178-82-1
ONC-201, also known as TIC10, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
Brimapitide Chemical Structure
 BCP46470 Brimapitide 1445179-97-4
Brimapitide is a protease resistant, potent inhibitor specific for JNK (JNK1, JNK2 and JNK3).
MK2-IN-1hydrochloride Chemical Structure
 BCP46469 MK2-IN-1hydrochloride 1314118-94-9
MK2-IN-1 hydrochloride is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.
PD184161 Chemical Structure
 BCP46466 PD184161 212631-67-9
PD184161 is an orally active MEK inhibitor. PD184161 inhibits MEK activity (IC50=10-100 nM) in a time- and concentration-dependent manner. PD184161 inhibits cell proliferation and induces apoptosis. PD184161 produces depressive-like behavior.
SM-7368 Chemical Structure
 BCP46452 SM-7368 380623-76-7
SM-7368 inhibits TNF-alpha-induced MMP-9 upregulation in a concentration-dependent manner. SM-7368 strongly inhibits the TNF-alpha-induced invasion of HT1080 human fibrosarcoma cell line.
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