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Signaling Pathways
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Protease/Metabolic Enzyme
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Research Areas
- Metabolic Disease
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Nature products
Antibodies
Peptides
Catalysts
Impurities
Intermediate
- Amino acid
- Ammonia Series
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- Azaindazole
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- Heterocyclic Series
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Raw Materials
MAPK Pathway
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP46296 | MNK1/2-IN-5 New | 1426928-20-2 |
MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor as a therapeutic agent.
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BCP46274 | SB-747651A New | 607372-46-3 |
SB-747651A is a specific mitogen- and stress-activated kinase 1 (MSK1) inhibitor. SB-747651A can be used for the research of inflammation.
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BCP46273 | SB-747651A dihydrochloride New | 1781882-72-1 |
SB-747651A dihydrochloride is a potent MSK1 inhibitor; also inhibiting other AGC group kinases.
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BCP43532 | Zunsemetinib New | 1640282-42-3 |
Zunsemetinib, also knoiwn as ATI-450 and CDD450, is a potent MK2 Inhibitor. ATI-450 binds with high affinity to the interface of the p38MAPK-MK2 complex and selectively inhibits p38MAPK-catalysed phosphorylation of MK2 which stabilises the inactive conformation of MK2, and subsequently reduces inflammatory cytokine levels. ATI-450 specifically blocks the downstream MK2-mediated inflammatory drive on the p38 pathway and may therefore avoid the tachyphylaxis associated with p38 inhibitors.
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BCP45842 | PF-05381941 New | 1474022-02-0 |
PF-05381941 is a novel potent dual TAK1/p38a inhibitor.
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BCP45765 | CMPD-1 New | 41179-33-3 |
CMPD-1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Kiapp) of 330 nM.
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BCP44458 | MK-2 Inhibitor III H2O New | 1186648-22-5 |
MK2-IN-3 hydrate is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM.
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BCP44104 | Encorafenib New | 1269440-29-0 |
Encorafenib is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells.
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BCP43938 | Rineterkib hydrochloride New | 1715025-34-5 |
Rineterkib is a RAF and ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models.
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BCP43705 | Indirubin-3'-oxime New | 667463-82-3 |
Indirubin-3'-monoxime, a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes.
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