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MAPK Pathway

Chemical Structure Cat. No. Product Name CAS No.
Vemurafenib-Analog Chemical Structure
 BCP27823 Vemurafenib-Analog 918505-61-0
Vemurafenib-Analog is a potent BRAF inhibitor and the isomer of Vemurafenib.
JNK-IN-8 Chemical Structure
 BCP24633 JNK-IN-8 1644498-56-5
JNK-IN-8 is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively.
APS-2-79 Chemical Structure
 BCP24938 APS-2-79 2002381-25-9
APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling.
SR15006 Chemical Structure
 BCP48958 SR15006 2505001-54-5
SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5) with an IC50 of 41.6 nM in DLD-1/pGL4.18hKLF5p cells.
ASK1-IN-2 Chemical Structure
 BCP48906 ASK1-IN-2 2541792-70-3
ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM.
FR 167653 sulfate Chemical Structure
 BCP25927 FR 167653 sulfate 158876-66-5
FR-167653 is a selective p38 MAPK inhibitor.
Selumetinib sulfate Chemical Structure
 BCP36547 Selumetinib sulfate 943332-08-9
Selumetinib Sulfate is the sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity.
OTS964 Chemical Structure
 BCP48392 OTS964 1338542-14-5
OTS964 is an orally active, high affinity and selective TOPK inhibitor with an IC50 of 28 nM.
GLPG-0259 Chemical Structure
 BCP48492 GLPG-0259 959754-85-9
GLPG-0259 is an inhibitor of mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5).
ASN007 benzenesulfonate Chemical Structure
 BCP48484 ASN007 benzenesulfonate 2055597-39-0
ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK. ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancers driven by RAS mutations.
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