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JAK

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JAK

Chemical Structure Cat. No. Product Name CAS No.
AZD4205 Chemical Structure
BCP46221 AZD4205 2091134-35-7
AZD4205 is a highly potent JAK1-selective kinase inhibitor with excellent preclinical pharmacokinetics with potential for further clinical development. JAK1 is part of the JAK1/signal transducer and activator of transcription (STAT) axis, which plays an important role in tumour escape from EGFR-targeted treatment.
Ifidancitinib Chemical Structure
BCP46085 Ifidancitinib 1236667-40-5
Ifidancitinib is a Janus kinase inhibitor.
Ritlecitinib tosylate Chemical Structure
BCP45991 Ritlecitinib tosylate 2192215-81-7
Ritlecitinib, also known as PF-06651600, is a potent and selective JAK3 inhibitor.
Deuruxolitinib phosphate Chemical Structure
BCP45990 Deuruxolitinib phosphate 2147706-60-1
Deuruxolitinib(CTP-543), an oral inhibitor of Janus kinases JAK1 and JAK2, as a potential treatment for alopecia areata.
JAK-IN-5 Chemical Structure
BCP45656 JAK-IN-5 2096999-92-5
JAK-IN-5 is an inhibitor of JAK.
Tyk2-IN-5 Chemical Structure
BCP45577 Tyk2-IN-5 1797432-62-2
Tyk2-IN-5 is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα.
Upadacitinib hemihydrate Chemical Structure
BCP41039 Upadacitinib hemihydrate 2050057-56-0
Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis.
Ilginatinib Chemical Structure
BCP44119 Ilginatinib 1239358-86-1
Ilginatinib is an orally bioavailable, small molecule inhibitor of Janus-associated kinase 2 (JAK2) and Src-family kinases, with potential antineoplastic activity. JAK2/Src inhibitor NS-018 competes with ATP for binding to JAK2 as well as the mutated form JAK2V617F, thereby inhibiting the activation of JAK2 and downstream molecules in the JAK2/STAT3 (signal transducer and activator of transcription 3) signaling pathway that plays an important role in normal development, particularly hematopoiesis. In addition, NS-018 inhibits the Src family tyrosine kinases. This eventually leads to the induction of tumor cell apoptosis.
Aurora B inhibitor 1 Chemical Structure
BCP42843 Aurora B inhibitor 1 937276-52-3
Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor extracted from patent WO2007059299A1, compound 1-3, has a Ki value of <0.010 uM.
BD750 Chemical Structure
BCP42671 BD750 892686-59-8
BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.
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