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Angiogenesis/Protein Tyrosine Kinase
  • Jak/Stat Pathway
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Chemical Structure Cat. No. Product Name CAS No.
Ruxolitinib racemic Chemical Structure
BCP25428 Ruxolitinib racemic 1160597-27-2
Ruxolitinib racemic is a Janus-associated kinase (JAK) inhibitor.
GDC-0214 Chemical Structure
BCP47996 GDC-0214 1831144-46-7
GDC0214 is a potent, selective inhalable and lung-restricted inhibitor of JAK1 with IC50 of 8.52 nM, displays 6.3/704/28 fold selectivity over JAK2/JAK3/TYK2.
JAK-IN-5 hydrochloride Chemical Structure
BCP48031 JAK-IN-5 hydrochloride 2751323-21-2
JAK-IN-5 is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283.
SJ10542 Chemical Structure
BCP46974 SJ10542 SJ10542
SJ10542 is JAK2/3 PROTAC. SJ10542 displayed high selectivity over GSPT1 and other members of the JAK family and potency in patient-derived ALL cells containing both JAK2 fusions and CRLF2 rearrangements.
G5-7 Chemical Structure
BCP46781 G5-7 939681-36-4
G5-7 is an orally active JAK2 inhibitor, selectively inhibits JAK2-mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 has the potential for glioma study.
SC99 Chemical Structure
BCP46780 SC99 882290-02-0
SC99 is a selective inhibitor of JAK2-STAT3 activation.
AZD4205 Chemical Structure
BCP46221 AZD4205 2091134-35-7
AZD4205 is a highly potent JAK1-selective kinase inhibitor with excellent preclinical pharmacokinetics with potential for further clinical development. JAK1 is part of the JAK1/signal transducer and activator of transcription (STAT) axis, which plays an important role in tumour escape from EGFR-targeted treatment.
Ifidancitinib Chemical Structure
BCP46085 Ifidancitinib 1236667-40-5
Ifidancitinib is a Janus kinase inhibitor.
Ritlecitinib tosylate Chemical Structure
BCP45991 Ritlecitinib tosylate 2192215-81-7
Ritlecitinib, also known as PF-06651600, is a potent and selective JAK3 inhibitor.
Deuruxolitinib phosphate Chemical Structure
BCP45990 Deuruxolitinib phosphate 2147706-60-1
Deuruxolitinib(CTP-543), an oral inhibitor of Janus kinases JAK1 and JAK2, as a potential treatment for alopecia areata.
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