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Epigenetic Reader Domain

Chemical Structure Cat. No. Product Name CAS No.
dBRD9 Chemical Structure
 BCP45901 dBRD9 2170679-45-3
dBRD9 is a potent and selective BRD9 bromodomain degrader composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide.
I-BET567 Chemical Structure
 BCP45484 I-BET567 1887237-54-8
I-BET567 is a potent and orally active inhibitor of pan-BET candidate with pIC50s of 6.9 and 7.2 for BRD4 BD1 and BD2, respectively.
Bet-IN-4 Chemical Structure
 BCP45446 Bet-IN-4 1801503-93-4
Bet-IN-4 is a highly potent, selective and orally active pan-BET inhibitor that has shown preclinical evidence of tumour growth inhibition in breast cancer and in leukaemia and prostate cancer xenograft models.
CTB Chemical Structure
 BCP45206 CTB 451491-47-7
CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.
PROTAC BRD4 ligand-1 Chemical Structure
 BCP45084 PROTAC BRD4 ligand-1 2313230-51-0
PROTAC BRD4 ligand-1 is a potent inhibitor of BET .
CYD19 Chemical Structure
 BCP44927 CYD19 CYD19
CYD19 is a novel potent CBP/p300-Snail interaction inhibitor, suppressing tumor growth and metastasis in wild-type p53-expressing cancer, forming a high-affinity interaction with the evolutionarily conserved arginine-174 pocket of Snail protein, reversing Snail-mediated epithelial-mesenchymal transition (EMT) and impairs EMT-associated tumor invasion and metastasis.
RVX297 Chemical Structure
 BCP43937 RVX297 1044871-04-6
RVX297 is a BD2 selective inhibitor of BET bromodomains. It is structurally related to the clinical compound RVX-208. It has significant implications on differential gene expression, which possibly can be further linked to the specific disease indication. It is currently undergoing phase III clinical trials for the treatment of cardiovascular diseases.
NI-42 Chemical Structure
 BCP43848 NI-42 1884640-99-6
NI 42 is a high affinity BRPF inhibitor (Kd values are 40, 210 and 943 nM for BRPF1B, 2 and 3, respectively). Also exhibits modest activity at BRD9 (Kd = 1130 nM). Exhibits selectivity for BRPF over 44 other bromodomains. Orally bioavailable.
GSK778 Chemical Structure
 BCP43559 GSK778 2451862-42-1
GSK778, also known as iBET-BD1, is a potent and selective inhibitor of bromodomain (BRD) BD1, with IC50s of 75 nM (BRD2 BD1).
CC-90010 Chemical Structure
 BCP43205 CC-90010 1706738-98-8
CC-90010 is a reversible, orally active and central nervous system-penetrant inhibitor of bromodomain and extra-terminal (BET) proteins. CC-90010 is applied in the study for advanced solid tumors.
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