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Apoptosis Pathway

Chemical Structure Cat. No. Product Name CAS No.
Erucin Chemical Structure
 BCP46130 Erucin 4430-36-8
Erucin is a natural product found in Thulinella chrysantha, Eruca vesicaria, and other organisms with data available.
SJ-172550 Chemical Structure
 BCP45444 SJ-172550 431979-47-4
SJ-172550 is an inhibitor of MDMX that disrupts MDMX-p53 peptide interaction with an EC50 value of 4.3 µM.
SMBA1 Chemical Structure
 BCP45276 SMBA1 906440-37-7
SMBA1 is a selective acrivator of Bax, a central death regulator. It acts by potently suppressing lung tumour growth via apoptosis.
(5Z,2E)-CU-3 Chemical Structure
 BCP45169 (5Z,2E)-CU-3 1815598-71-0
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM.
BMS-8 Chemical Structure
 BCP45103 BMS-8 1675201-90-7
BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface, binding at a hydrophobic cavity formed upon PD-L1 dimerization.
M351-056 Chemical Structure
 BCP44929 M351-056 M351-056
M351-056 is a novel VISTA (V-domain immunoglobulin suppressor of T-cell activation) agonist.
M351-110 Chemical Structure
 BCP44928 M351-110 M351-110
M351-110 is a novel VISTA (V-domain immunoglobulin suppressor of T-cell activation) agonist.
ZZW-115 3HCl Chemical Structure
 BCP44912 ZZW-115 3HCl 10122-45-9
ZZW-115 hydrochloride is a potent NUPR1 inhibitor, with a Kd of 2.1 μM.
NAE-IN-M22 Chemical Structure
 BCP44660 NAE-IN-M22 864420-54-2
NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo.
Necrostatin-34 Chemical Structure
 BCP44627 Necrostatin-34 375835-43-1
Necrostatin-34, a RIPK1 kinase inhibitor, stabilizes RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
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