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Apoptosis Pathway

Chemical Structure Cat. No. Product Name CAS No.
ONC-201 Dihydrochloride Chemical Structure
 BCP46830 ONC-201 Dihydrochloride 1638178-82-1
ONC-201, also known as TIC10, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
NiCur Chemical Structure
 BCP46796 NiCur 63476-70-0
NiCur is an inhibitor of p53 with an IC50 value of 0.35 μM.
SP141 Chemical Structure
 BCP46465 SP141 1253491-42-7
SP 141 is a cell-permeable inhibitor of Mdm2 (Ki = 28 nM).
Erucin Chemical Structure
 BCP46130 Erucin 4430-36-8
Erucin is a natural product found in Thulinella chrysantha, Eruca vesicaria, and other organisms with data available.
SJ-172550 Chemical Structure
 BCP45444 SJ-172550 431979-47-4
SJ-172550 is an inhibitor of MDMX that disrupts MDMX-p53 peptide interaction with an EC50 value of 4.3 µM.
SMBA1 Chemical Structure
 BCP45276 SMBA1 906440-37-7
SMBA1 is a selective acrivator of Bax, a central death regulator. It acts by potently suppressing lung tumour growth via apoptosis.
(5Z,2E)-CU-3 Chemical Structure
 BCP45169 (5Z,2E)-CU-3 1815598-71-0
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM.
BMS-8 Chemical Structure
 BCP45103 BMS-8 1675201-90-7
BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface, binding at a hydrophobic cavity formed upon PD-L1 dimerization.
M351-056 Chemical Structure
 BCP44929 M351-056 M351-056
M351-056 is a novel VISTA (V-domain immunoglobulin suppressor of T-cell activation) agonist.
M351-110 Chemical Structure
 BCP44928 M351-110 M351-110
M351-110 is a novel VISTA (V-domain immunoglobulin suppressor of T-cell activation) agonist.
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