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Raw Materials
p53
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP46796 | NiCur New | 63476-70-0 |
NiCur is an inhibitor of p53 with an IC50 value of 0.35 μM.
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BCP43517 | CP-31398 dihydrochloride New | 1217195-61-3 |
CP-31398 dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
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BCP32609 | PK11007 New | 874146-69-7 |
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels.
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BCP29278 | (−)-Nutlin-3 New | 548472-68-0 |
Nutlin 3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM.
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BCP30143 | PK11007 New | 38275-34-2 |
PK11007 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
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BCP17578 | Pifithrin-β hydrobromide New | 511296-88-1 |
Pifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM.
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BCP14611 | CP 31398 New | 259199-65-0 |
CP 31398 dihydrochloride is a potent activator of p53 with maximum tolerated dose of 400 ppm.
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BCP29977 | CBL0137 New | 1197996-80-7 |
CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 μM and inhibits NF-κB with an EC50 of 0.47 μM.
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BCP26191 | Prima-1 | 5608-24-2 |
Prima-1 is an inhibitor of the growth of cell lines derived from various human tumor types in a mutant p53-dependent manner.
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BCP28961 | COTI-2 | 1039455-84-9 |
COTI-2 is a small molecule candidate anti-cancer drug which can convert mutant p53 to wild-type conformation.
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