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Wnt/Stem Cell

Chemical Structure Cat. No. Product Name CAS No.
K-975 Chemical Structure
 BCP44951 K-975 2563855-03-6
K-975 is a first-in-class TEAD inhibitor, directly inhibiting YAP/TAZ-TEAD protein-protein interaction and showing a potent anti-tumor effect in malignant pleural mesothelioma.
Dalosirvat Chemical Structure
 BCP44837 Dalosirvat 1360540-81-3
Dalosirvat is a topical Wnt pathway activator for the treatment of androgenetic alopecia (AGA).
Stafia-1 Chemical Structure
 BCP44460 Stafia-1 Stafia-1
Stafia-1 decreases pSTAT5a expression significantly, and has no obvious inhibition on pSTAT5b.
β-catenin/CBP-IN-1 Chemical Structure
 BCP44122 β-catenin/CBP-IN-1 1198780-38-9
β-catenin/CBP-IN-1 (CBP/β-catenin inhibitor) is a potent and selective CBP/β-catenin inhibitor, extracted from the patent WO2014092154A1.
Dynarrestin Chemical Structure
 BCP44170 Dynarrestin 2222768-84-3
Dynarrestin is a dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.
Ilginatinib Chemical Structure
 BCP44119 Ilginatinib 1239358-86-1
Ilginatinib is an orally bioavailable, small molecule inhibitor of Janus-associated kinase 2 (JAK2) and Src-family kinases, with potential antineoplastic activity. JAK2/Src inhibitor NS-018 competes with ATP for binding to JAK2 as well as the mutated form JAK2V617F, thereby inhibiting the activation of JAK2 and downstream molecules in the JAK2/STAT3 (signal transducer and activator of transcription 3) signaling pathway that plays an important role in normal development, particularly hematopoiesis. In addition, NS-018 inhibits the Src family tyrosine kinases. This eventually leads to the induction of tumor cell apoptosis.
STAT3-IN-3 Chemical Structure
 BCP43810 STAT3-IN-3 2361304-26-7
STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3).
FOXY-5 Chemical Structure
 BCP43701 FOXY-5 881188-51-8
FOXY-5 is a Wnt5a peptide mimetic. It has been undergoing clinical trials for the treatment of prostate cancer, colorectal cancer, metastatic colon cancer, metastatic breast cancer, and metastatic prostate cancer.
Heparitin, sulfate Chemical Structure
 BCP43695 Heparitin, sulfate 9050-30-0
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.
Indirubin-3'-oxime Chemical Structure
 BCP43705 Indirubin-3'-oxime 667463-82-3
Indirubin-3'-monoxime, a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes.
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