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5 HT Receptor/Serotonin Receptor

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5 HT Receptor/Serotonin Receptor

Chemical Structure Cat. No. Product Name CAS No.
Temanogrel Chemical Structure
 BCP24269 Temanogrel 887936-68-7
Temanogrel is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.
NAS-181 methanesulfonate Chemical Structure
 BCP49052 NAS-181 methanesulfonate 205242-62-2
NAS-181 methanesulfonate is a 5-HT(1B) receptor antagonist.
Sarizotan Chemical Structure
 BCP24751 Sarizotan 351862-32-3
Sarizotan is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively.
Opiranserin Chemical Structure
 BCP48961 Opiranserin 1441000-45-8
Opiranserin is a glycine transporter inhibitor and serotonin receptor antagonist. Opiranserin is a drug candidate.
DOI hydrochloride Chemical Structure
 BCP25643 DOI hydrochloride 42203-78-1
DOI hydrochloride is a brain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)-α.
8-OH-Dpat Chemical Structure
 BCP25681 8-OH-Dpat 78950-78-4
8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).
Prucalopride hydrochloride Chemical Structure
 BCP48408 Prucalopride hydrochloride 179474-80-7
Prucalopride hydrochloride is a selective 5-HT4 agonist.
RU-24969 Chemical Structure
 BCP48648 RU-24969 66611-26-5
RU-24969 is a potent, selective agonist of 5-HT1A and 5-HT1B receptors, with preference for 5-HT1B.
(Z)-Thiothixene Chemical Structure
 BCP48214 (Z)-Thiothixene 3313-26-6
Thiothixene is a modulator of human P-glycoprotein and is frequently used a an anti-psychotic.
WAY-161503 Chemical Structure
 BCP48258 WAY-161503 75704-24-4
WAY-161503 is a full agonist of 5-HT2C receptors that exhiits ~6-fold less potent at 5-HT2A receptors (Ki = 18 nM) and 20-fold less potent at 5-HT2B receptors (Ki = 60 nM).
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