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Raw Materials
Aurora
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP42843 | Aurora B inhibitor 1 New | 937276-52-3 |
Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor extracted from patent WO2007059299A1, compound 1-3, has a Ki value of <0.010 uM.
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BCP35921 | SP-146 New | SP-146 |
SP-146 is a potent, selective and non-ATP-competitive inhibitor of Aurora B with IC50 of 0.316 nM.
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BCP33311 | Phthalazinone pyrazole New | 880487-62-7 |
Phthalazinone pyrazole is a potent, selective and orally bioavailable inhibitor of Aurora-A kinase.
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BCP30248 | Aurora Kinase Inhibitor III New | 879127-16-9 |
Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).
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BCP28083 | Cenisertib New | 871357-89-0 |
Cenisertib selectively binds to and inhibits aurora kinases (AKs), a family of serine-threonine kinases which are important regulators of cell division and proliferation, and which are overexpressed in certain types of cancer.
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BCP29563 | CCT241736 | 1402709-93-6 |
CCT241736 is a novel, orally bioavailable, imidazo[4,5-b]pyridine derivative discovered at our Institute, highly selective for FLT3 and Aurora kinases with an S(10) selectivity score using KINOMEscan™ technology of 0.057 (fraction of 386 non-mutant kinases inhibited >90% when screened at 1 uM of CCT241736; San Diego, CA).
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BCP11714 | AT9283 | 896466-04-9 |
AT9283 is a multi-targeted inhibitor with IC50s of 1.2 nM, 1.1 nM for JAK2 and JAK3, respectively, and is also potent to Aurora A, Aurora B and Abl(T315I).
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BCP07256 | Ilorasertib | 1227939-82-3 |
ABT-348, is a novel potent and orally bioavailable inhibitor of the Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases and is currently in Phase I clinical trials.
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BCP15994 | BI 847325 | 1207293-36-4 |
BI-847325 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.
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