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Potassium Channel

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Potassium Channel

Chemical Structure Cat. No. Product Name CAS No.
AMP PNP Chemical Structure
BCP46541 AMP PNP 72957-42-7
AMP PNP is a non-hydrolyzable AMP analog.
Vernakalant hydrochloride Chemical Structure
BCP45728 Vernakalant hydrochloride 748810-28-8
Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker. IC50 for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channelwt, Kv1.5 channelI508F, Kv1.5 channelT479A, respectively.
Terfenadine Chemical Structure
BCP43974 Terfenadine 50679-08-8
Terfenadine is a potent open-channel blocker of hERG with a mean IC50 of 204 nM.
A2793 Chemical Structure
BCP42593 A2793 88349-90-0
A2793 is an efficient inhibitor of TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK.
NS8593 hydrochloride Chemical Structure
BCP41256 NS8593 hydrochloride 875755-24-1
NS8593 HCl is a selective KCa2 channel negative modulator.
ASP-2905 Chemical Structure
BCP41250 ASP-2905 792184-90-8
ASP2905 is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3).
NS 3623 Chemical Structure
BCP40735 NS 3623 343630-41-1
NS 3623 is a KV11.1 (hERG) and KV4.3 channel activator. It can activate the IKr and Ito currents and display antiarrhythmic activity.
PD-118057 Chemical Structure
BCP39203 PD-118057 313674-97-4
PD-118057 is a hERG channel enhancer. Human ether-a-go-go-related gene 1 (hERG1) K(+) channels mediate repolarization of cardiac action potentials.
BL-1249 Chemical Structure
BCP39202 BL-1249 18200-13-0
BL-1249 is a selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator.
XE 991 Chemical Structure
BCP39201 XE 991 122955-42-4
XE991 is a potent and selective KCNQ channel blocker. XE991 blocks KCNQ2+3/M-currents (IC50 = 0.6-0.98 μM) and KCNQ1 homomeric channels (IC50 = 0.75 μM) but is less potent against KCNQ1/minK channels (IC50 = 11.1 μM).
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