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Potassium Channel

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Potassium Channel

Chemical Structure Cat. No. Product Name CAS No.
AZD-5672 Chemical Structure
 BCP48543 AZD-5672 780750-65-4
AZD-5672 is an orally active, potent, selective CCR5 antagonist. AZD-5672 shows moderate activity against the hERG ion channel. AZD5672 is used for the research of rheumatoid arthritis.
1-EB10 Chemical Structure
 BCP47348 1-EB10 10045-45-1
1-EBIO is an activator of Ca2+-sensitive K+ channels with an EC50 of 490 µM in T84 cells.
Branaplam hydrochloride Chemical Structure
 BCP48029 Branaplam hydrochloride 1562338-39-9
Branaplam hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN.
AMP PNP Chemical Structure
 BCP46541 AMP PNP 72957-42-7
AMP PNP is a non-hydrolyzable AMP analog.
Vernakalant hydrochloride Chemical Structure
 BCP45728 Vernakalant hydrochloride 748810-28-8
Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker. IC50 for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channelwt, Kv1.5 channelI508F, Kv1.5 channelT479A, respectively.
Terfenadine Chemical Structure
 BCP43974 Terfenadine 50679-08-8
Terfenadine is a potent open-channel blocker of hERG with a mean IC50 of 204 nM.
A2793 Chemical Structure
 BCP42593 A2793 88349-90-0
A2793 is an efficient inhibitor of TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK.
NS8593 hydrochloride Chemical Structure
 BCP41256 NS8593 hydrochloride 875755-24-1
NS8593 HCl is a selective KCa2 channel negative modulator.
ASP-2905 Chemical Structure
 BCP41250 ASP-2905 792184-90-8
ASP2905 is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3).
NS 3623 Chemical Structure
 BCP40735 NS 3623 343630-41-1
NS 3623 is a KV11.1 (hERG) and KV4.3 channel activator. It can activate the IKr and Ito currents and display antiarrhythmic activity.
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