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Jak/Stat Pathway
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Chemical Structure Cat. No. Product Name CAS No.
inS3-54-A18 Chemical Structure
BCP48402 inS3-54-A18 328998-53-4
inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.
Stafia-1 Chemical Structure
BCP45558 Stafia-1 2582757-90-0
Stafia-1 is a the first potent and selective STAT5a inhibitor, displaying high selectivity over STAT5b and other STAT family members.
FLLL31 Chemical Structure
BCP46782 FLLL31 52328-97-9
FLLL31, derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects.
SC99 Chemical Structure
BCP46780 SC99 882290-02-0
SC99 is a selective inhibitor of JAK2-STAT3 activation.
RSVA 405 Chemical Structure
BCP46773 RSVA 405 140405-36-3
RSVA-405 is a potent STAT3 inhibitor and is an analog of resveratol.
L002 Chemical Structure
BCP46453 L002 321695-57-2
L-002 is an inhibitor of p300 histone acyltransferase (KAT3B). L-002 also inhibits acetylation of histones and p53 and suppresses STAT3 activation. In vivo, L-002 potently suppressed tumor growth of TNBC cell line MDA-MB-468 xenografts.
BUN34616 Chemical Structure
BCP46436 BUN34616 2111834-61-6
BUN34616 is a potent and selective inhibitor of phosphorylation and transcriptional activity of STAT5.
SC-1 Chemical Structure
BCP46435 SC-1 1313019-65-6
SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.
Stafia-1 Chemical Structure
BCP44460 Stafia-1 Stafia-1
Stafia-1 decreases pSTAT5a expression significantly, and has no obvious inhibition on pSTAT5b.
STAT3-IN-3 Chemical Structure
BCP43810 STAT3-IN-3 2361304-26-7
STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3).
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