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Cell Cycle/DNA Damage

Chemical Structure Cat. No. Product Name CAS No.
CDK4/6-IN-6 Chemical Structure
BCP46270 CDK4/6-IN-6 2380321-51-5
CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
Bisantrene dihydrochloride Chemical Structure
BCP46265 Bisantrene dihydrochloride 71439-68-4
Bisantrene Hydrochloride is the hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the helical structure of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.
CDK5-IN-3 Chemical Structure
BCP46220 CDK5-IN-3 2639542-32-6 
CDK5-IN-3 is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively.
Zn-C3 Chemical Structure
BCP46219 Zn-C3 2376146-48-2
ZN-c3 is a highly selective Wee1 inhibitor (ICV50 = 3.8 nM) with balanced potency, ADME, and pharmacokinetic properties. ZN-c3 showed excellent in vivo efficacy and is currently being evaluated in phase 2 clinical trials.
DHODH-IN-16 Chemical Structure
BCP41511 DHODH-IN-16 2511248-11-4
DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH.
Sovilnesib Chemical Structure
BCP46107 Sovilnesib 2410796-79-9
Sovilnesibum is a kinesin-like protein KIF18A inhibitor.
Chk2 Inhibitor Chemical Structure
BCP46034 Chk2 Inhibitor 724708-21-8
Chk2 inhibitor is an inhibitor of checkpoint kinase 2 (Chk2).
TH5427 Chemical Structure
BCP46030 TH5427 2253744-56-6
TH5427 is a potent, selective NUDT5 inhibitor (IC50=29 nM).
HSP27 inhibitor J2 Chemical Structure
BCP46015 HSP27 inhibitor J2 2133499-85-9
HSP27 inhibitor J2 is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function.
NPX800 Chemical Structure
BCP45963 NPX800 1693734-80-3
NPX-800 is a potent, selective, oral heat shock factor 1 (HSF1) pathway inhibitor.
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