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Pyruvate Kinase

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Pyruvate Kinase

Chemical Structure Cat. No. Product Name CAS No.
Mitapivat sulfate anhydrous Chemical Structure
 BCP47994 Mitapivat sulfate anhydrous 2329710-91-8
Mitapivat sulfate anhydrous is an allosteric activator of Pyruvate Kinase (PK) that may be useful in the treatment of Pyruvate Kinase Deficiency.
Etavopivat Chemical Structure
 BCP46430 Etavopivat 2245053-57-8
Etavopivat (FT-4202) is an orally administered, small-molecule allosteric activator of erythrocyte pyruvate kinase-R (PKR) development for the treatment of sickle cell disease and other hemoglobin disorders.
PKR-IN-C51 Chemical Structure
 BCP34854 PKR-IN-C51 1314594-23-4
PKR-IN-C51 is a protein kinase R (PKR) inhibitor.
Mitapivat Chemical Structure
 BCP19727 Mitapivat 1260075-17-9
Mitapivat, also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
PKM2 inhibitor Chemical Structure
 BCP23555 PKM2 inhibitor 94164-88-2
PKM2 inhibitor is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 μM.
DASA-58 Chemical Structure
 BCP16322 DASA-58 1203494-49-8
DASA-58 is a selective activator of pyruvate kinase M2 (PKM2; AC50 = 38 nM in vitro, EC50 = 19.6 μM in cells).DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins.
Shikonin Chemical Structure
 BCP29329 Shikonin 517-89-5
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin has shown various biological activities, including inhibition of TNF-α, NF-κB, HIV-1.
ML265 Chemical Structure
 BCP12877 ML265 1221186-53-3
ML265 is a potent and selective activator of recombinant pyruvate kinase M2 (PKM2) with half-maximum activating concentration (AC50 value) of 92 nM, and little or no activity versus PKM1, PKL and PKR.
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