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Nature products
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Raw Materials
CFTR
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP48256 | RTC13 New | 313530-30-2 |
RTC13 is a premature termination codon (PTC) readthrough inducer that acts by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.
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BCP21194 | Icenticaftor New | 1334546-77-8 |
Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC50s of 79 nM and 497 nM for F508del and G551D CFTR, respectively.
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BCP43623 | Crinecerfont hydrochloride New | 321839-75-2 |
Crinecerfont is a potent and orally bioactive corticotropin-releasing factor 1 receptor (CRF1) antagonist (pKi values of 8.73 and 9.08 for human cloned or native CRF1 receptors, respectively) with 1000-fold selectivity for CRF1 over CRF2α receptor and CRF binding protein.
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BCP35907 | Elexacaftor R enantiomer New | 2229860-99-3 |
Elexacaftor (VX-445,) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
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BCP19794 | Deutivacaftor New | 1413431-07-8 |
Deutivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator potentially for the treatment of cystic fibrosis.
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BCP29711 | Elexacaftor New | 2216712-66-0 |
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). CFTR corrector 1 (compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
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BCP30546 | FDL169 New | 1628416-28-3 |
FDL169 is an experimental therapy for cystic fibrosis (CF) that is being developed by Flatley Discovery Lab.
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BCP29456 | VX-659 | 2204245-48-5 |
VX-659 is a CFTR protein inhibitor.
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BCP25130 | ABBV-2222 | 1918143-53-9 |
ABBV-2222, also known as GLPG2222, is a CFTR corrector being studied for the treatment of cystic fibrosis (CF).
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BCP07173 | Tezacaftor New Discount | 1152311-62-0 |
Tezacaftor, also known asVX-661, is CFTR modulator. VX-661 is potentially useful for treatment of cystic fibrosis disease. Cystic fibrosis (CF) is a genetic disease caused by defects in the CF transmembrane regulator (CFTR) gene, which encodes an epithelial chloride channel. The most common mutation, Δ508CFTR, produces a protein that is misfolded and does not reach the cell membrane. VX-661 can correct trafficking of Δ508CFTR and partially restore chloride channel activity.
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