CC-92480
| CAS号 | 2259648-80-9 | 货号 | BCP32805 |
| 中文名 | CC-92480 | ||
| 英文名 | CC-92480 | ||
| 中文别名 | |||
| 英文别名 | CC 92480; CC92480; | ||
| 分子式 | C32H30FN5O4 | 分子量 | 567.62 |
| 生物活性 | CC-92480 is a cereblon E3 ubiquitin ligase modulating agent with potential immunomodulating and antineoplastic activities. CC-92480 specifically binds to cereblon (CRBN), thereby affecting the ubiquitin E3 ligase activity, and targeting certain substrate proteins for ubiquitination. This induces proteasome-mediated degradation of certain transcription factors, some of which are transcriptional repressors in T cells. This leads to modulation of the immune system, including activation of T lymphocytes, and downregulation of the activity of other proteins, some of which play key roles in the proliferation of certain cancer cell types. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | E1 E2 E3 Enzyme | ||
结构式
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