MBM-55
| CAS No. | 2083622-09-5 | Cat. No. | BCP32925 |
| Name | MBM-55 | ||
| Synonyms | MBM 55;MBM55; | ||
| Formula | C28H27FN6O2 | M. Wt | 498.55 |
| Description | MBM-55 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM. MBM-55 shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice. | ||
| Pathways | Apoptosis Pathway | ||
Structure
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