他莫昔芬
| CAS号 | 10540-29-1 | 货号 | BCP33248 |
| 中文名 | 他莫昔芬 | ||
| 英文名 | Tamoxifen | ||
| 中文别名 | 三苯氧胺,它莫西芬; | ||
| 英文别名 | ICI 46474; ICI-46474; ICI46474; (Z)-Tamoxifen; trans-Tamoxifen; | ||
| 分子式 | C26H29NO | 分子量 | 371.51 |
| 生物活性 | Tamoxifen is a selective estrogen receptor modulator (SERM) and antagonist of ER action in breast tissue and breast cancer cells. It is reported to be effective in the treatment of early breast cancer to prevent tumor growth. Importantly, tamoxifen has been reported to act as an ER agonist in bone and blood vessels, helping to minimize osteoporosis and reduce the risk of cardiovascular disease in post-menopausal women. Also, tamoxifen is a partial ER agonist in uterine tissues and is reported to increase the risk of endometrial carcinoma. | ||
| 信号通路 | Protease/Metabolic Enzyme Cell Cycle/DNA Damage Hormone Pathay | ||
| 靶 点 | Estrogen Receptor HSP | ||
结构式
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