Azvudine

  • Chemical Properties
CAS No. 1011529-10-4 Cat. No. BCP34041
Name Azvudine
Synonyms RO-0622;RO 0622;RO0622;
Formula C9H11FN6O4 M. Wt 286.22
  • Biological Activity
Description Azvudine is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains[1]. Azvudine is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
Pathways Microbiology/Virology 
Targets Reverse Transcriptase 

Structure

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