盐酸司来吉兰
| CAS号 | 14611-52-0 | 货号 | BCP38874 |
| 中文名 | 盐酸司来吉兰 | ||
| 英文名 | Selegiline hydrochloride | ||
| 中文别名 | 盐酸丙炔苯并胺;司来吉兰盐酸盐;盐酸司立吉林; | ||
| 英文别名 | Selegiline Hcl; | ||
| 分子式 | C13H18ClN | 分子量 | 223.74 |
| 生物活性 | Selegiline Hydrochloride is the hydrochloride salt form of selegiline, a levorotatory acetylenic derivative of phenethylamine with antiparkinsonian effect. As a selective monoamine oxidase (MAO) inhibitor, selegiline has the greatest affinity for type B MAO, found mainly in the brain. Selegiline is converted by MAO B to an active moiety, which binds irreversibly at the active site of the enzyme's cofactor FAD (flavin adenine dinucleotide) molecule. This prevents the oxidative deamination of catecholamines and serotonin by MAO B, and leads to an increase in these neurotransmitters' activities resulting in improved motor function. In addition, this agent may inhibit re-uptake of dopamine by the neuron and prolong dopamine activity. | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | Monoamine Oxidase | ||
结构式
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