DDO-5936
  • 化学数据
CAS号 2355377-13-6 货号 BCP42338
中文名 DDO-5936
英文名 DDO-5936
中文别名
英文别名 DDO 5936; DDO5936;
分子式 C25H29N5O4S 分子量 495.59
  • 用途
生物活性 DDO-5936 is a potent PPI inhibitor targeting Hsp90-Cdc37 protein-protein interaction (PPI) as Orally Active Inhibitors for the Treatment of Colorectal Cancer. DDO-5936 disrupted the Hsp90-Cdc37 PPI both in vitro and in vivo via binding to a previously unknown site on Hsp90 involving Glu47, one of the binding determinants for the Hsp90-Cdc37 PPI, leading to selective down-regulation of Hsp90 kinase clients in HCT116 cells. In addition, inhibition of Hsp90-Cdc37 complex formation by DDO-5936 resulted in a remarkable cyclin-dependent kinase 4 decrease and consequent inhibition of cell proliferation through Cdc37-dependent cell cycle arrest.
信号通路 Protease/Metabolic Enzyme Cell Cycle/DNA Damage 
靶 点 HSP 

结构式

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