Shepherdin
| CAS号 | 861224-28-4 | 货号 | BCP42633 |
| 中文名 | Shepherdin | ||
| 英文名 | Shepherdin | ||
| 中文别名 | |||
| 英文别名 | NSC-741765; NSC741765; NSC 741765; | ||
| 分子式 | C41H64N12O12S | 分子量 | 949.09 |
| 生物活性 | Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms.Shepherdin 79-87 is amino acids 79 to 87 fragment of Shepherdin. Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms. Conversely, shepherdin does not reduce the viability of normal cells nor affect colony formation of purified hematopoietic progenitors. Systemic administration of shepherdin in vivo is well tolerated, and inhibits human tumor growth in mice without toxicity. | ||
| 信号通路 | Protease/Metabolic Enzyme Cell Cycle/DNA Damage | ||
| 靶 点 | HSP | ||
结构式
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