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Shepherdin 结构式

Shepherdin

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货号 :BCP42633CAS号 :861224-28-4纯度:98%
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  • 基本信息与产品描述
CAS号 861224-28-4 货号 BCP42633
中文名 Shepherdin
英文名 Shepherdin
中文别名
英文别名 NSC-741765; NSC741765; NSC 741765;
SMILES CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(=O)O)C(C)(C)C)NC(=O)C(CS)NC(=O)CNC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CC2=CN=CN2)NC(=O)C(CCCCN)N
化学名称
分子式 C41H64N12O12S 分子量 949.09
纯度 98% 配送 惯例下常温包邮
产品描述 Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms.Shepherdin 79-87 is amino acids 79 to 87 fragment of Shepherdin. Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms. Conversely, shepherdin does not reduce the viability of normal cells nor affect colony formation of purified hematopoietic progenitors. Systemic administration of shepherdin in vivo is well tolerated, and inhibits human tumor growth in mice without toxicity.
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