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| CAS号 | 423145-35-1 | 货号 | BCP48933 |
| 中文名 | YUM70 | ||
| 英文名 | YUM70 | ||
| 中文别名 | |||
| 英文别名 | YUM-70; YUM 70; | ||
| SMILES | CCCC(=O)NC(C1=CC2=C(C=C1)OCO2)C3=CC(=C4C=CC=NC4=C3O)Cl | ||
| 化学名称 | |||
| 分子式 | C21H19ClN2O4 | 分子量 | 398.84 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | YUM70 is a potent inhibitor of GRP78 (Glucose-regulated protein, 78 kDa). YUM70, inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues. YUM70 directly bound GRP78 and inactivated its function, resulting in ER stress-mediated apoptosis. A YUM70 analog conjugated with BODIPY show co-localization of the compound with GRP78 in the ER. Moreover, a YUM70-PROTAC (PROteolysis TArgeting Chimera) was synthesized to force degradation of GRP78 in pancreatic cancer cells. YUM70 showed a strong synergistic cytotoxicity with topotecan and vorinostat. | ||
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