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| CAS号 | 1061318-81-7 | 货号 | BCP27980 |
| 中文名 | Debio 0932 | ||
| 英文名 | Debio 0932 | ||
| 中文别名 | |||
| 英文别名 | Debio0932; Debio-0932; CUDC305; CUDC-305; CUDC 305; | ||
| SMILES | CC(C)(C)CNCCN1C2=C(C(=NC=C2)N)N=C1SC3=CC4=C(C=C3N(C)C)OCO4 | ||
| 化学名称 | |||
| 分子式 | C22H30N6O2S | 分子量 | 442.58 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Debio 0932, also known as CUDC-305, is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance. | ||
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