Debio 0932
  • 化学数据
CAS号 1061318-81-7 货号 BCP27980
中文名 Debio 0932
英文名 Debio 0932
中文别名
英文别名 Debio0932; Debio-0932; CUDC305; CUDC-305; CUDC 305;
分子式 C22H30N6O2S 分子量 442.58
  • 用途
生物活性 Debio 0932, also known as CUDC-305, is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance.
信号通路 Protease/Metabolic Enzyme Cell Cycle/DNA Damage 
靶 点 HSP 

结构式

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