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| CAS号 | 911398-13-5 | 货号 | BCP48982 |
| 中文名 | BIIB028 | ||
| 英文名 | BIIB028 | ||
| 中文别名 | |||
| 英文别名 | BIIB 028; BIIB-028; | ||
| SMILES | CC1=CN=C(C(=C1OC)C)CN2C=C(C3=C2N=C(N=C3Cl)N)C#CCCOP(=O)(O)O | ||
| 化学名称 | |||
| 分子式 | C19H21ClN5O5P | 分子量 | 465.83 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to other molecules involved in cell cycle regulation and immune responses. | ||
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