BIIB028
| CAS号 | 911398-13-5 | 货号 | BCP48982 |
| 中文名 | BIIB028 | ||
| 英文名 | BIIB028 | ||
| 中文别名 | |||
| 英文别名 | BIIB 028; BIIB-028; | ||
| 分子式 | C19H21ClN5O5P | 分子量 | 465.83 |
| 生物活性 | BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to other molecules involved in cell cycle regulation and immune responses. | ||
| 信号通路 | Protease/Metabolic Enzyme Cell Cycle/DNA Damage | ||
| 靶 点 | HSP | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！