YUM70
| CAS号 | 423145-35-1 | 货号 | BCP48933 |
| 中文名 | YUM70 | ||
| 英文名 | YUM70 | ||
| 中文别名 | |||
| 英文别名 | YUM-70; YUM 70; | ||
| 分子式 | C21H19ClN2O4 | 分子量 | 398.84 |
| 生物活性 | YUM70 is a potent inhibitor of GRP78 (Glucose-regulated protein, 78 kDa). YUM70, inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues. YUM70 directly bound GRP78 and inactivated its function, resulting in ER stress-mediated apoptosis. A YUM70 analog conjugated with BODIPY show co-localization of the compound with GRP78 in the ER. Moreover, a YUM70-PROTAC (PROteolysis TArgeting Chimera) was synthesized to force degradation of GRP78 in pancreatic cancer cells. YUM70 showed a strong synergistic cytotoxicity with topotecan and vorinostat. | ||
| 信号通路 | Protease/Metabolic Enzyme Cell Cycle/DNA Damage | ||
| 靶 点 | HSP | ||
结构式
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