AS1269574
| CAS号 | 330981-72-1 | 货号 | BCP43461 |
| 中文名 | AS1269574 | ||
| 英文名 | AS1269574 | ||
| 中文别名 | |||
| 英文别名 | AS-1269574; AS 1269574; | ||
| 分子式 | C13H14BrN3O | 分子量 | 308.17 |
| 生物活性 | AS1269574 is a GPR119 agonist. AS1269574 activates an outwardly rectifying membrane current with properties expected of TRPA1 channels. AS1269574 had an EC(50) value of 2.5μM in HEK293 cells transiently expressing human GPR119 and enhanced insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8mM) conditions. In in vivo studies, a single administration of AS1269574 to normal mice reduced blood glucose levels after oral glucose loading based on the observed insulin secretion profiles. Significantly, AS1269574 did not affect fed and fasting plasma glucose levels in normal mice. AS1269574 represents a novel structural class of small molecule, orally administrable GPR119 agonists with GSIS and promising potential for the treatment of type 2 diabetes. | ||
| 信号通路 | Hormone Pathay GPCR/G Protein | ||
| 靶 点 | GPR | ||
结构式
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