Tetomilast
| CAS No. | 145739-56-6 | Cat. No. | BCP45927 |
| Name | Tetomilast | ||
| Synonyms | OPC6535; OPC-6535; OPC 6535; | ||
| Formula | C19H18N2O4S | M. Wt | 370.42 |
| Description | Tetomilast, also known as OPC6535, is a novel thiazole phosphodiesterase-4 (PDE-4) inhibitor, which may prove useful in both the treatment of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). Tetomilast attenuates elastase-induced pulmonary emphysema through inhibition of oxidative stress in rabbits. Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phosphodiesterase/PDE | ||
Structure
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