SBP-7455
| CAS No. | 1884222-74-5 | Cat. No. | BCP48924 |
| Name | SBP-7455 | ||
| Synonyms | SBP7455; SBP 7455; | ||
| Formula | C16H17F3N4O2 | M. Wt | 354.33 |
| Description | SBP-7455 is a dual inhibitors of ULK1 and ULK2 (ULK1/2). It displayed improved binding affinity for ULK1/2 compared with SBI-0206965, potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice. SBP-7455 inhibited starvation-induced autophagic flux in TNBC cells. | ||
| Pathways | Others Pathway | ||
| Targets | Autophagy | ||
Structure
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