Indoximod

CAS No.	110117-83-4	Cat. No.	BCP08015
Name	Indoximod
Synonyms	NLG-8189;NLG 8189;NLG8189;1-Methyl-D-tryptophan;
Formula	C12H14N2O2	M. Wt	218.25

Description	1-Methyl-D-tryptophan is an inhibitor of the enzymes IDO and INDOL1 (indolamine 2,3-dioxygenase 1 and 2) with selectivity for INDOL1. The enzymes perform similar transformations and are responsible for catalyzing the rate-limiting step of oxidative tryptophan catabolism in the kynurenine pathway. IDO activity is correlated with an induction of tolerance and immunosuppresion through activation of regulatory T cells by metabolites generated from tryptophan catabolism. Inhibition of IDO by 1-Methyl-D-tryptophan blocks this induced immune suppression, which has shown utility in suppressing acquired immunities of tumors and indicates potential for chemical intervention of chronic inflammatory diseases.
Pathways	Protease/Metabolic Enzyme
Targets	IDO

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