StemRegenin 1
| CAS号 | 1227633-49-9 | 货号 | BCP07738 |
| 中文名 | StemRegenin 1 | ||
| 英文名 | StemRegenin 1 | ||
| 中文别名 | |||
| 英文别名 | StemRegenin1;SR-1;SR1;SR 1; | ||
| 分子式 | C24H23N5OS | 分子量 | 429.54 |
| 生物活性 | The compound StemRegenin 1 (SR1) is a selective, cell permeable, small molecule that promotes the self-renewal of human hematopoietic stem cells in culture. SR1 is an antagonist of the aryl hydrocarbon receptor.SR1 is the first small molecule that promotes robust expansion/self-renewal of human CD34+ peripheral blood and cord blood hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. SR1 can be potentially used for ex vivo expansion of normal HSCs or leukemic stem/progenitor cells. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | AhR | ||
结构式
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