ARRY-520
  • 化学数据
CAS号 885060-09-3 货号 BCP07442
中文名 ARRY-520
英文名 ARRY-520
中文别名
英文别名 ARRY520;ARRY 520; Filanesib;
分子式 C20H22F2N4O2S 分子量 420.47
  • 用途
生物活性 ARRY-520 is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents. KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.
信号通路 Cell Cycle/DNA Damage 
靶 点 Kinesin 

结构式

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