ARRY-520

参考资料仅供科学研究，不可用于个人用途。

货号：BCP07442CAS号：885060-09-3纯度：98%

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CAS号	885060-09-3	货号	BCP07442
中文名	ARRY-520
英文名	ARRY-520
中文别名
英文别名	ARRY520;ARRY 520; Filanesib;
SMILES
化学名称
分子式	C20H22F2N4O2S	分子量	420.47
纯度	98%	配送	惯例下常温包邮
产品描述	ARRY-520 is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents. KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.