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| CAS号 | 336113-53-2 | 货号 | BCP02450 |
| 中文名 | 伊斯平斯 | ||
| 英文名 | Ispinesib | ||
| 中文别名 | |||
| 英文别名 | SB-715992; SB 715992; SB715992; CK 0238273; CK-0238273; CK0238273; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C30H33ClN4O2 | 分子量 | 517.06 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Ispinesib is a potent, specific and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM. Ispinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. | ||
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