AZD4877

参考资料仅供科学研究，不可用于个人用途。

货号：BCP07430CAS号：1176760-49-8纯度：98%

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CAS号	1176760-49-8	货号	BCP07430
中文名	AZD4877
英文名	AZD4877
中文别名
英文别名	AZD-4877;AZD 4877;
SMILES
化学名称
分子式	C28H33N5O2S	分子量	503.66
纯度	98%	配送	惯例下常温包邮
产品描述	AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. Eg5 is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.