普伐他汀
| CAS号 | 81093-37-0 | 货号 | BCP21480 |
| 中文名 | 普伐他汀 | ||
| 英文名 | Pravastatin | ||
| 中文别名 | 帕伐他丁; | ||
| 英文别名 | CS-514;CS 514;CS514; | ||
| 分子式 | C23H36O7 | 分子量 | 424.53 |
| 生物活性 | Pravastatin is an antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase with IC50 of 5.6 μM. It is used in combination with diet, exercise, and weight loss for lowering cholesterol and preventing cardiovascular disease. It is a synthetic lipid-lowering agent. It lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing major histocompatibility complex II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. It is primarily used for the treatment of dyslipidemia and the prevention of cardiovascular disease. It is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | HMGCR | ||
结构式
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