Evofosfamide
| CAS No. | 918633-87-1 | Cat. No. | BCP06074 |
| Name | Evofosfamide | ||
| Synonyms | TH-302;TH 302;TH302; | ||
| Formula | C9H16Br2N5O4P | M. Wt | 449.04 |
| Description | Evofosfamide, also known as TH-302, is a hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity. Check for active clinical trials or closed clinical trials using this agent. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA Alkylator/Crosslinker | ||
Structure
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