优立替尼
| CAS号 | 869886-67-9 | 货号 | BCP04232 |
| 中文名 | 优立替尼 | ||
| 英文名 | Ulixertinib | ||
| 中文别名 | |||
| 英文别名 | 1956366-10-1; BVD-523; BVD 523; BVD523; VRT752271; VRT752271; VRT 752271;; | ||
| 分子式 | C21H22Cl2N4O2 | 分子量 | 433.33 |
| 生物活性 | Ulixertinib, also known as BVD-523 and VRT752271, is an inhibitors of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | MEK/ERK | ||
结构式
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