BNC105P
| CAS号 | 945771-96-0 | 货号 | BCP04200 |
| 中文名 | BNC105P | ||
| 英文名 | BNC105P | ||
| 中文别名 | |||
| 英文别名 | BNC105P; BNC 105P; BNC-105P; | ||
| 分子式 | C20H19O10P.2Na | 分子量 | 496.32 |
| 生物活性 | BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, depriving tumor cells of nutrients and resulting in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. BNC105 is not a substrate for the multidrug-resistance P-glycoprotein (Pgp) transporter. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Cell Cycle/DNA Damage | ||
| 靶 点 | Microtubule VDA | ||
结构式
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