BNC105P

参考资料仅供科学研究，不可用于个人用途。

货号：BCP04200CAS号：945771-96-0纯度：98%

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CAS号	945771-96-0	货号	BCP04200
中文名	BNC105P
英文名	BNC105P
中文别名
英文别名	BNC105P; BNC 105P; BNC-105P;
SMILES
化学名称
分子式	C20H19O10P.2Na	分子量	496.32
纯度	98%	配送	惯例下常温包邮
产品描述	BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, depriving tumor cells of nutrients and resulting in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. BNC105 is not a substrate for the multidrug-resistance P-glycoprotein (Pgp) transporter.