奥瑞布林

参考资料仅供科学研究，不可用于个人用途。

货号：BCP07754CAS号：181816-48-8纯度：98%

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CAS号	181816-48-8	货号	BCP07754
中文名	奥瑞布林
英文名	Ombrabulin
中文别名
英文别名	AVE-8062; AVE 8062; AVE8062;
SMILES
化学名称
分子式	C21H26N2O6	分子量	402.44
纯度	98%	配送	惯例下常温包邮
产品描述	Ombrabulin is a synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), with potential vascular-disrupting and antineoplastic activities. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells. As apoptotic endothelial cells detach from their substrata, tumor blood vessels collapse; the acute disruption of tumor blood flow may result in tumor necrosis. Ombrabulin was discovered by Ajinomoto and under development by Sanofi-Aventis. It is currently in Phase III clinical trials for the treatment of advanced-stage soft-tissue sarcoma. Ombrabulin was granted orphan drug status by the European Medicines Agency in April 2011. Ombrabulin is a combretastatin A-4 derivative that exerts its antitumor effect by disrupting the formation of blood vessels needed for tumor growth.