NKP-1339

参考资料仅供科学研究，不可用于个人用途。

货号：BCP26252CAS号：197723-00-5纯度：98%

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CAS号	197723-00-5	货号	BCP26252
中文名	NKP-1339
英文名	NKP-1339
中文别名
英文别名	NKP 1339;NKP1339;KP1339;KP 1339;KP-1339;
SMILES	[Cl-][Ru+3]([N]1=CC2=CC=CC=C2N1)([Cl-])([Cl-])([N]3=CC4=CC=CC=C4N3)[Cl-].[Na+]
化学名称
分子式	C14H12Cl4N4NaRu	分子量	502.14
纯度	98%	配送	惯例下常温包邮
产品描述	NKP-1339, also known as KP-1339, is a ruthenium-containing cancer agent targeting transferrin with potential antineoplastic activity. Upon intravenous administration, NKP-1339 (Ru3+) binds to transferrin (Tf) and is taken up via Tf receptors (TfR), which are overexpressed on cancer cells. Once inside the cell, NKP-1339 is released from Tf and is reduced, within the acidic environment of the endosomes, to its active form NKP-119 (Ru2+). In turn, the active form induces a redox reaction, thereby leading to the formation of reactive oxygen species (ROS) which inhibits GRP78 and SOD, endoplasmic reticulum-stress modulating molecules as well as BAG4 and ERK, program cell death regulating molecules.This eventually induces caspase-dependent apoptosis.