BNC105

参考资料仅供科学研究，不可用于个人用途。

货号：BCP19547CAS号：945771-74-4纯度：98%

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CAS号	945771-74-4	货号	BCP19547
中文名	BNC105
英文名	BNC105
中文别名
英文别名	BNC-105;BNC 105;
SMILES
化学名称
分子式	C20H20O7	分子量	372.37
纯度	98%	配送	惯例下常温包邮
产品描述	BNC105 is a novel compound being developed by Bionomics as a Vascular Disrupting Agent (VDA) for treatment of cancer. VDAs are drugs that disrupt the blood vessels that nourish tumours. BNC105 acts as a tubulin polymerization inhibitor and displays 80-fold higher potency against endothelial cells than that of CA4P. CA4P is a VDA currently under evaluation in phase III clinical trials. BNC105 is more potent and offers a wider therapeutic window. CA4P produces 90% vascular disruption at its no observed adverse event level (NOAEL), whereas BNC105 causes 95% vascular disruption at 1/8th of its NOAEL. Tissue distribution analysis of BNC105 in tumor-bearing mice showed that while the drug is cleared from all tissues 24 hours after administration, it is still present at high concentrations within the solid tumor mass. Furthermore, BNC105 treatment causes tumor regressions with complete tumor clearance in 20% of treated animals.