BMS-777607
| CAS No. | 1025720-94-8 | Cat. No. | BCP02303 |
| Name | BMS-777607 | ||
| Synonyms | 1196681-44-3;BMS817378; BMS 817378; BMS-817378; BMS777607;BMS 777607; ASLAN 002; ASLAN-002; ASLAN002; | ||
| Formula | C25H19ClF2N4O4 | M. Wt | 512.89 |
| Description | BMS-777607, also known as BMS-817378 and ASLAN-002, a Met tyrosine kinase inhibitor, is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis. | ||
| Related Products | 1196681-44-3 （BMS 777607） | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | TAM Receptor c Met | ||
Structure
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