阿巴瑞克
| CAS号 | 183552-38-7 | 货号 | BCP27629 |
| 中文名 | 阿巴瑞克 | ||
| 英文名 | Abarelix | ||
| 中文别名 | |||
| 英文别名 | PPI149; PPI-149; PPI 149; R3827; R-3827; R 3827; | ||
| 分子式 | C72H95ClN14O14 | 分子量 | 1416.08 |
| 生物活性 | Abarelix is a synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | GnRH Receptor | ||
结构式
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