特罗司他乙酯
| CAS号 | 1033805-22-9 | 货号 | BCP02293 |
| 中文名 | 特罗司他乙酯 | ||
| 英文名 | Telotristat ethyl | ||
| 中文别名 | |||
| 英文别名 | LX-1606;LX 1606;LX1606; | ||
| 分子式 | C27H26ClF3N6O3 | 分子量 | 574.98 |
| 生物活性 | Telotristat Ethyl is the ethyl ester form of telotristat, a tryptophan hydroxylase (TPH) inhibitor, with potential anti-serotonergic activity. Upon administration, telotristat binds to and inhibits the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Tryptophan Hydroxylase/TPH | ||
结构式
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