Pemetrexed

  • Chemical Properties
CAS No. 137281-23-3 Cat. No. BCP27649
Name Pemetrexed
Synonyms LY231514;LY 231514;LY-231514;
Formula C20H21N5O6 M. Wt 427.41
  • Biological Activity
Description Pemetrexed is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively.
Pathways Cell Cycle/DNA Damage 
Targets DHFR 

Structure

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