维莫德吉
| CAS号 | 879085-55-9 | 货号 | BCP01715 |
| 中文名 | 维莫德吉 | ||
| 英文名 | Vismodegib | ||
| 中文别名 | |||
| 英文别名 | GDC-0449;GDC 0449;GDC0449; RG3616; RG 3616; RG-3616; | ||
| 分子式 | C19H14Cl2N2O3S | 分子量 | 421.31 |
| 生物活性 | Vismodegib, also known as GDC-0449 or RG3616, is a hedgehog antagonist, is also a n orally bioavailable small molecule with potential antineoplastic activity. Hedgehog antagonist GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. | ||
| 信号通路 | Wnt/Stem Cell | ||
| 靶 点 | Hedgehog | ||
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Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production
购于瀚香生物(Biochempartner)的维莫德吉(CAS:879085-55-9)被引用 |
|
Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia
购于瀚香生物(Biochempartner)的维莫德吉(CAS:879085-55-9)被引用 |
结构式
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